About project

Basic information about the project

Project ID APVV-14-0294
Project start 01.07.2015
Project end 30.06.2018
R&D specialization 20430 – Biomedical engineering

Annotation

Clinical practice recently requires an alternative for implants manufactured from titanium alloys, which are optimal for specific types of individual anatomical defects of hard tissues. Project solves production and testing of individual hard tissues scaffolds made of hydroxyapatite (HA) by 3D printing technology (3DP). One of the advantages of  3DP is its possibility to produce free form implants with applicated porous structures for better osseointegration. These tissues will be tested from material, biomechanical and biological point of view and prepared for clinical applications.

Basic information of participating organizations

Applicant

Name of the organization Technical University of Kosice, Faculty of Mechanical engineering
Address of the organization Letná 9, 042 00, Košice
IČO/ID 00397610
Príslušnosť k rezortu MŠVVaŠ SR
Form management Vysoká škola
Phone 055/602 2016
E-mail rektor@tuke.sk
Štatutárny zástupca Dr.h.c. prof., Ing. Čižmár Anton, CSc.

Cooperative organization

Name of the organization Comenius University in Bratislava, Faculty of medicine
Address of the organization Šafárikova námestie 6, 818 06 Bratislava
IČO/ID 00397865
Príslušnosť k rezortu MŠVVaŠ SR
Form management University
Phone 02/5935 7471
E-mail cpp@fmed.uniba.sk
Štatutárny zástupca prof. RNDr. Mičieta Karol, PhD.

Cooperative organization

Name of the organization ICARST, no.
Address of the organization Jamnického 19, 841 04 Bratislava
IČO/ID 45736260
Príslušnosť k rezortu Bez príslušnosti
Form management Non-profit organization
Phone +421 904 905 409
Štatutárny zástupca prof., Ing. Miertuš Stanislav, DrSc.

Project

Key words:

Hydroxyapatite (HA), 3D printing, additive manufacturing, biological testing, biomechanics, materials testing

Objectives of the project:

The main objective of the project is the manufacture of hydroxyapatite implants using two manufacture technologies, testing and mutual comparisons of these technologies from the biomechanical, material and biological point of view, and the preparation of the comprehensive material for the clinical application. This objective consists of the following partial objectives:

  • market research update,
  • manufacture of HA customised implants using the 3D-Bioplotter,
  • manufacture of HA customised implants using the LCM technology,
  • material tests of HA customised implants,
  • biomechanical simulations and tests of HA customised implants,
  • computer-assisted modelling of hydroxyapatite surface and adsorption of proteins on the HA surface, as well as membrane components of osteocytes, to explain and possibly design the modifications of hydroxyapatite structure surfaces,
  • biological testing of HA implants – biocompatibility and cytotoxicity of human diploid fibroblasts models,
  • preparation of a comparative study and result analysis,
  • preparation of a feasibility study for clinical applications of customised HA implants on the basis of the test results.

Phase project

  1. Stage 1 (July 2015 – December 2015) – update of marker research and activities within the research and development, methodology preparation and the project solution procedure,
  2. Stage 2 (January 2016 – April 2016) – procurement of necessary technologies within the ordinary expenses and the material for the execution of research and development tasks,
  3. Stage 3 (May 2016 – August 2016) – CAD/CAM modelling and manufacture of experimental samples at the applicant’s workplace and by means of external services,
  4. Stage 4 (September 2016 – April 2017) – execution of material and biomechanical tests, including computer-assisted modelling of hydroxyapatite surface and adsorption of proteins on the HA surface, as well as membrane components of osteocytes to explain and possibly design the modifications of hydroxyapatite structure surfaces,
  5. Stage 5 (May 2017 – December 2018) – biological testing of HA implants – biocompatibility and cytotoxicity to models of human diploid fibroblasts,
  6. Stage 6 (January 2018 – May 2018) – preparation of a comparative study and a result analysis and preparation of a feasibility study for the clinical applications of customised HA implants based on the testing results.